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Updated: Feb 19, 2026

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
Published on: June 27, 2025
Multivariate closed-loop model for analysis of cardiovascular dynamics
1VTT Information Technology, Tampere, Finland. Ilkka.Korhonen@vtt.fi
Abstract:
This paper introduces a closed-loop model for the analysis of interactions between heart rate and blood pressure variability, and respiration. The respiratory influence is modeled with an anti-causal structure to control the possible phase lead of heart rate to instantaneous lung volume. The closed-loop structure between heart rate and blood pressure allows the analysis of inter-relationships between the signals. Simulations and results on experimental data show the identifiability of the model and the robustness of the noise source contribution analysis over a wide range of model orders.
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