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Craniofacial zygomycosis caused by Apophysomyces elegans

A Chakrabarti1, N Panda, S C Varma

  • 1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Mycoses
|February 21, 1998
PubMed
Summary

A rare fatal craniofacial zygomycosis caused by Apophysomyces elegans occurred in a myelofibrosis patient. Diagnosis involved identifying fungal hyphae in tissue and isolating the fungus.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Pathology

Background:

  • Craniofacial zygomycosis is a severe fungal infection, often associated with immunocompromised states.
  • Apophysomyces elegans is a rare but aggressive fungus implicated in zygomycosis.

Observation:

  • A 52-year-old male with idiopathic myelofibrosis, thrombocytopenia, and mild hyperglycemia presented with craniofacial zygomycosis.
  • Diagnostic methods included microscopic examination of tissue from paranasal sinuses and fungal culture.

Findings:

  • Broad, aseptate, branched hyaline hyphae characteristic of Apophysomyces elegans were identified in patient tissue.
  • The fungus was successfully isolated from the paranasal sinus tissue, confirming the causative agent.

Implications:

Related Experiment Videos

  • This case highlights the aggressive nature of Apophysomyces elegans in immunocompromised individuals.
  • It represents the second documented instance of craniofacial zygomycosis caused by this specific fungus, emphasizing the need for clinical awareness.