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Cyanotic Raynaud's phenomenon with conventional but not with liposomal amphotericin B: three case reports
B Zernikow1, G Fleischhack, C Hasan
1Department of Paediatric, Haematology/Oncology, University Children's Hospital, University of Bonn, Germany.
Mycoses
|February 21, 1998
Abstract:
Despite its common adverse effects intravenous (i.v.) amphotericin B is an indispensable antifungal drug in childhood oncology. We report here on three cases of painful cyanotic Raynaud's phenomenon after i.v. administration or inhalation of amphotericin B. A liposomal i.v. preparation of amphotericin B was well tolerated by the infants. Spasms of peripheral vessels mediated by thromboxane A2 could be responsible for the Raynaud's phenomenon. Hence, inhibitors of prostaglandin synthesis are suggested for therapy.