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Related Experiment Videos

Platelets in rat anaphylaxis

L Fésüs, B Csaba, L Muszbek

    Acta Allergologica
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Severe anaphylactic shock (AS) causes a rapid drop in circulating platelets, likely due to an aggregating factor. These platelets are cleared by the spleen, contributing to bleeding issues.

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    Area of Science:

    • Immunology
    • Hematology
    • Pharmacology

    Background:

    • Anaphylactic shock (AS) is a severe systemic reaction.
    • Platelet dynamics during AS are not fully understood.
    • Understanding AS pathophysiology is crucial for treatment.

    Purpose of the Study:

    • To investigate the changes in circulating platelet count during AS.
    • To identify factors responsible for platelet reduction in AS.
    • To determine the fate of platelets during AS and their impact on hemostasis.

    Main Methods:

    • Induction of severe anaphylactic shock in rats.
    • Monitoring of platelet counts before and after AS.
    • Administration of Persantin and heparin as pretreatment.
    • Organ distribution studies using 51Cr-labeled platelets.

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  • Assessment of rat tail bleeding time.

    • Main Results:

    • Circulating platelet numbers decreased abruptly in the early phase of AS.
    • Persantin pretreatment inhibited this decrease, while heparin did not.
    • Aggregated platelets were primarily cleared by the spleen, with some trapped in the lungs and small intestine.
    • The remaining platelets maintained functional integrity.
    • Rat tail bleeding time was prolonged, indicating impaired hemostasis.

    Conclusions:

    • A platelet aggregating factor, possibly released during anaphylaxis, causes the drop in platelet count.
    • Platelet sequestration in the spleen, lungs, and intestines contributes to hemostatic disturbances in AS.
    • The findings highlight the role of platelets in the pathophysiology of anaphylactic shock.