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[Hepatotropic GB and G viruses]
1Unidad de Patología, Hospital General de México, SS, Facultad de Medicina, UNAM, México, D.F.
Insights
This review covers GB viruses (GBV-A, GBV-B, GBV-C), noting GBV-C/HGV is parenterally transmitted and infects over 10% of hepatitis patients, though its pathogenicity remains unclear.
Area of Science:
- Virology
- Hepatology
- Infectious Diseases
Context:
- Review of the discovery and characteristics of GB viruses (GBV-A, GBV-B, and GBV-C).
- Exploration of the relationship between GB Virus-C (GBV-C) and Hepatitis G Virus (HGV).
- GBV-A and GBV-B are not associated with human liver disease.
Purpose:
- To present a review of the discovery of GB viruses.
- To discuss the transmission routes and prevalence of GBV-C/HGV.
- To highlight the undefined pathogenicity of GBV-C/HGV.
Summary:
- GB Virus-C (GBV-C), also known as Hepatitis G Virus (HGV), is transmitted parenterally via blood transfusions or contaminated needles, leading to chronic infections.
- Prevalence of GBV-C/HGV infection is low (<1%) in blood donors but high (>10%) in patients with Hepatitis B or C.
- The specific role and pathogenicity of GBV-C/HGV in human disease are not well-defined.
Impact:
- Provides a consolidated overview of GB viruses, aiding researchers in understanding their discovery and implications.
- Highlights the epidemiological significance of GBV-C/HGV in specific patient populations.
- Underscores the need for further research into the pathogenicity of GBV-C/HGV.
Abstract:
A review of the discovery of the GB viruses (GB virus-A, GB virus-B and GB virus-C) is presented, and the relationship between the GB virus-C and the hepatitis G virus (HGV) is mentioned. The GB virus-A and GB virus-B apparently do not cause liver disease in human. The GB virus C, HGV or GBV-C/HGV is transmitted parenterally, usually through blood transfusions or contaminated needles causing chronical infection. The prevalence of GBV-C/HGV infection among volunteer blood donors is less than 1%, and in patients with C or B hepatitis is more than 10%; the pathogenicity of this agent is not well defined.