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Published on: May 14, 2020
Clinical profile and outcome in 52 patients with cardiac pseudoaneurysm
1Mayo Clinic, Rochester, Minnesota, USA.
Insights
Cardiac pseudoaneurysm, a contained rupture, can be asymptomatic or present with various symptoms. Surgical repair is often preferred, but conservative management may be suitable for high-risk patients as no further ruptures were observed.
Area of Science:
- Cardiology
- Cardiac Surgery
- Cardiovascular Research
Background:
- Cardiac pseudoaneurysm, a form of contained cardiac rupture, poses a risk of further rupture.
- Limited data exists on the clinical profile and natural history of cardiac pseudoaneurysm.
Purpose of the Study:
- To investigate the clinical features and patient outcomes associated with cardiac pseudoaneurysm.
- To analyze the natural history and management strategies for cardiac pseudoaneurysm.
Main Methods:
- Retrospective analysis of 52 patients diagnosed with cardiac pseudoaneurysm between 1980 and 1996.
- Data collected from Mayo Clinic locations, including patient demographics, clinical presentation, diagnostic methods, etiology, location, and treatment outcomes.
Main Results:
- 48% of patients were asymptomatic at diagnosis; presentations included acute myocardial infarction, cardiac tamponade, heart failure, chest pain, syncope, and embolism.
- Pseudoaneurysm etiology was linked to cardiac surgery (58%) or myocardial infarction (42%).
- Surgical repair was performed in 81% of patients with a 7% mortality rate; 19% received conservative management. No further ruptures occurred.
Conclusions:
- A significant proportion of cardiac pseudoaneurysm cases are asymptomatic.
- While surgical repair is the primary treatment, conservative management is a viable option for select patients with high surgical risk, given the absence of rupture-related deaths.
Background:
Cardiac pseudoaneurysm, a contained cardiac rupture, predisposes patients to further rupture. However, knowledge of the clinical profile and natural history of this cardiac complication is limited.
Objective:
To study the clinical features and outcomes of patients with cardiac pseudoaneurysm.
Design:
Retrospective analysis of patients with cardiac pseudoaneurysm seen between January 1980 and September 1996.
Setting:
Mayo Clinic in Rochester, Minnesota; Scottsdale, Arizona; and Jacksonville, Florida.
Patients:
52 patients with pseudoaneurysm.
Results:
Pseudoaneurysm was discovered incidentally in 25 asymptomatic patients (48%). Four patients (8%) presented acutely (3 with acute myocardial infarction and 1 with cardiac tamponade). Other clinical presentations were congestive heart failure in 8 patients (15%), chest pain in 7 (13%), syncope or arrhythmia in 5 (10%), and systemic embolism in 3 (6%). Initial diagnostic tests were echocardiography in 32 patients, cardiac catheterization in 12, magnetic resonance imaging in 4, and computed tomography in 2. Diagnosis was made intraoperatively in two patients. Pseudoaneurysm occurred after cardiac surgery in 30 patients (58%) and after myocardial infarction in 22 (42%). Location of the pseudoaneurysm was primarily related to its cause: Pseudoaneurysm was located in the inferior or posterolateral wall in 18 of 22 patients (82%) after myocardial infarction, in the right ventricular outflow tract in 13 of 15 patients (87%) after congenital heart surgery, in the posterior subannular region of the mitral valve in 4 of 4 patients (100%) after mitral valve replacement, and in the subaortic region in 3 of 3 (100%) after aortic valve replacement. Forty-two patients (81%) had surgical repair (surgical mortality rate, 7%). Ten patients (19%) did not have surgery. Nineteen patients died after a median survival of 2.3 years (range, 3 days to 8.2 years): Eight died of noncardiac cause, 5 of congestive heart failure, 4 of acute myocardial infarction, and 2 of cardiac arrhythmia (ventricular tachycardia). No further cardiac ruptures were documented.
Conclusions:
A substantial number of patients with pseudoaneurysm are asymptomatic. Although surgical repair is the treatment of choice, conservative management in selected patients with increased surgical risk seems reasonable because no deaths were caused by further rupture.
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