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Computed tomographic study of aged schizophrenic patients

H Seno1, M Shibata, A Fujimoto

  • 1Department of Psychiatry, Shimane Medical University, Izumo, Japan.

Psychiatry and Clinical Neurosciences
|February 24, 1998
PubMed
Summary
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This study found enlarged brain ventricles and fissures in elderly schizophrenia patients, consistent with younger patients. Advanced third ventricle enlargement may correlate with reduced positive and depressive symptoms in aged individuals.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Gerontology

Background:

  • Schizophrenia is associated with structural brain changes.
  • Previous research indicates ventricular enlargement in schizophrenia, but studies on elderly populations are less common.

Purpose of the Study:

  • To investigate brain structural differences in elderly chronic schizophrenia patients compared to controls.
  • To explore the relationship between ventricular size and psychiatric symptoms in aged schizophrenic individuals.

Main Methods:

  • Cranial computed tomography (CT) was used to measure the width of the interhemispheric fissure, lateral ventricles, and third ventricle.
  • Participants included 45 elderly inpatients with chronic schizophrenia and 28 age-matched controls.
  • Cognitive and psychiatric assessments included the Mini-Mental State Examination and the Brief Psychiatric Rating Scale (BPRS).

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Main Results:

  • Significant enlargement of the interhemispheric fissure and ventricular system was observed in aged schizophrenic patients compared to controls.
  • Ventricular enlargement was more pronounced in male patients than in female patients.
  • A correlation was found between third ventricle enlargement and reduced positive and depressive symptoms.

Conclusions:

  • Structural brain abnormalities, including ventricular enlargement, persist in elderly individuals with chronic schizophrenia.
  • Third ventricle enlargement may have a potential therapeutic effect on positive and depressive symptoms in this population.