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Severe neurological complications in association with Epstein-Barr virus infection
E P Corssmit1, M A Leverstein-van Hall, P Portegies
1Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
Journal of Neurovirology
|February 25, 1998
Abstract:
Involvement of the nervous system in infectious mononucleosis is common. About 50% have headache on presentation. Neck stiffness without meningitis is a frequent finding. Severe neurological complications are rare though, occurring in fewer than 0.5%. We describe two patients with unusual and severe neurological complications in association with serological evidence of EBV-infection: a 32-year old female developed a bilateral optic neuritis combined with a transverse myelitis and a 72-year old man developed mononeuritis multiplex, autonomic neuropathy and a salt-wasting nephropathy.