Hematocolpos caused by genital bullous lesions in a patient with Stevens-Johnson syndrome

We report a case of complete vaginal fusion with subsequent development of hematocolpos in a 14-year-old sexually inactive girl previously treated for Stevens-Johnson syndrome. The epidermal disease was likely precipitated by Mycoplasma pneumoniae pneumonia. The patient presented with lower abdominal cramping and amenorrhea that had persisted for 5 months. Sonography demonstrated a markedly distended vagina filled with echogenic fluid. A diagnosis of hematocolpos secondary to Stevens-Johnson syndrome was rendered, and the patient underwent surgery with incision of the fused introitus and drainage of about 300 ml of dark blood. While unusual, this case demonstrates that hematocolpos should be considered in patients with a history of epidermal bullous disease and amenorrhea.