Related Experiment Video
Updated: Aug 17, 2026

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
Published on: April 1, 2018
Depression in attention deficit hyperactivity disorder (ADHD) children: "true" depression or demoralization?
J Biederman1, E Mick, S V Faraone
1Pediatric Psychopharmacology Unit (ACC 725), Massachusetts General Hospital, Boston 02114, USA.
Background:
The purpose of this study was to further evaluate the nature of the association between major depression (MD) and attention deficit hyperactivity disorder (ADHD) by examining predictors of persistence of MD attending to issues of familiality, adversity and comorbidity.
Methods:
Four years of follow-up of 76 depressed ADHD children were analyzed using multivariate regression to determine predictors of persistent MD.
Results:
Bipolar disorder and higher indices of interpersonal problems predicted MD persistence. In contrast, school difficulty and ADHD-associated measures of severity were not associated with persistent MD. Remission from ADHD was also not statistically significantly associated with remission from MD.
Conclusions:
ADHD and MD had independent and distinct courses, indicating that ADHD-associated MD reflects a depressive disorder and not merely demoralization.
Limitations:
This study may have reduced power due to stratification of our group of ADHD boys with persistent and remitting MD.
More Related Videos
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
10:02Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
Published on: March 12, 2020
Related Concept Videos
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depression: Overview
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Oppositional Defiant Disorder
Diagnostic Criteria and...