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Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome
S M Allen1, J N Freeman, W M Davis
1Department of Pharmacology and the Research Institute of Pharmacological Sciences, University of Mississippi, University 38677, USA.
Pharmacology, Biochemistry, and Behavior
|February 26, 1998
Abstract:
Rats were treated as neonates with 6-hydroxydopamine (6-OHDA) 100 mg free base in 10 microl intracisternally. Upon maturation, animals were injected with L-dopa and placed in photocell cages for monitoring of locomotion, stereotypies, and self-mutilation. Pretreatment with either risperidone or SCH-23390 significantly reduced locomotion and stereotypies. SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject.