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Chromatin remodeling machines: similar motors, ulterior motives
1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. cairns@rascal.med.harvard.edu
Trends in Biochemical Sciences
|March 28, 1998
Abstract:
Chromatin is a dynamic material; chromatin structures can repress transcription and their remodeling accompanies activation. Recent biochemical studies in Drosophila have revealed three multi-protein complexes with ATP-dependent chromatin restructuring activities. Although all contain the ATPase ISWI, their properties in vitro are markedly different, distinct from SWI-SNF and reveal intriguing connections to both transcription and chromatin assembly.