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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
[Immunomodulating action of blood component therapy in cancer patients]
1Military Medical Academy, St.Petersburg.
Abstract:
The influence of blood-component therapy on the immune system in cancer patients (non-Hodgkin's lymphoma-33; intestinal adenocarcinoma-15) has been evaluated. Blood transfusions were found to change the activity of such components and factors of the immune system as B-lymphocytes, T-suppressors, tumor necrosis and interleukin-1, without major reactions of antitumor immunity being inhibited. Initial immunological status appeared to be a very important factor of immune processes. It is suggested that leukocyte-free blood alone be used for transfusions since leukocytes are suspected of producing an immuno-suppressive effect.
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