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[Ex-vivo bleeding time as a control for platelet transfusion]
D Söhngen1, E Hattstein, A Heyll
1Abteilung für Hämatologie, Onkologie und klinische Immunologie, Medizinische Klinik und Poliklinik, Heinrich-Heine-Universität, Düsseldorf, Deutschland.
Beitrage Zur Infusionstherapie Und Transfusionsmedizin = Contributions to Infusion Therapy and Transfusion Medicine
|January 1, 1994
Summary
Platelet transfusions are crucial for treating thrombocytopenia, especially in acute leukemia patients. This study highlights factors influencing transfusion effectiveness and a new method for assessing platelet function in low counts.
Area of Science:
- Hematology
- Oncology
Background:
- Thrombocytopenia is a primary cause of bleeding disorders.
- Platelet transfusion is the standard treatment for impaired platelet production.
- Prophylactic platelet transfusion is recommended for acute leukemia patients with platelet counts below 20 x 10(9)/l.
Purpose of the Study:
- To analyze the effectiveness of platelet transfusions in acute myelocytic leukemia (AML).
- To identify factors influencing platelet transfusion efficacy beyond simple count increment.
- To evaluate a modified method for assessing platelet function at low platelet counts.
Main Methods:
- Retrospective analysis of 231 acute myelocytic leukemia (AML FAB M1-7) patients.
- Evaluation of bleeding complications and early-death rates.
- Assessment of platelet transfusion effectiveness considering clinical factors and a modified platelet function test.
Main Results:
- Bleeding complications contributed to an early-death rate of 7.7% in AML patients.
- Transfusion effectiveness is influenced by fever, sepsis, hepato-splenomegaly, and medication use, not just corrected count increment (CCI).
- A modified platelet function test allows evaluation even with platelet counts below 50 x 10(9)/l.
Conclusions:
- Platelet transfusion is vital for managing thrombocytopenia in acute leukemia.
- Comprehensive assessment, including clinical factors, is necessary to determine transfusion effectiveness.
- The modified platelet function test offers a valuable tool for evaluating platelet function in critically low counts.