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[Bronchial reactivity in diabetic patients]
M Pieron1, A J Scheen, J L Corhay
1Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Sart Tilman, Liège, Belgique.
Revue Des Maladies Respiratoires
|February 28, 1998
Summary
Diabetic autonomic neuropathy may affect respiratory vagal innervation. Diabetic patients with cardiac autonomic neuropathy (CAN) showed reduced bronchial reactivity during methacholine challenges compared to those without CAN or healthy individuals.
Area of Science:
- Pulmonary Medicine
- Diabetology
- Neurology
Background:
- Bronchial reactivity in diabetic patients is debated.
- Diabetic cardiac autonomic neuropathy (CAN) affects the autonomic nervous system.
Purpose of the Study:
- To investigate the impact of CAN on bronchial reactivity in diabetics.
- To assess ventilatory parameters during methacholine challenge in diabetic patients with and without CAN.
Main Methods:
- Compared 10 diabetic patients with CAN, 10 without CAN, and 10 healthy controls.
- Assessed cardiac autonomic function using heart rate variability tests.
- Administered methacholine challenge to measure bronchial response and ventilatory parameters.
Main Results:
- Diabetic patients with CAN exhibited significantly less bronchoconstriction after methacholine exposure.
- No significant difference in bronchial response was observed between healthy subjects and diabetic patients without CAN.
- Cardiac autonomic function was assessed via heart rate changes during deep breathing, Valsalva maneuver, and orthostatism.
Conclusions:
- Diabetic autonomic neuropathy appears to extend to the vagal innervation of the respiratory tract.
- CAN may alter airway responsiveness in diabetic individuals.
- Further research is warranted to elucidate the mechanisms of respiratory involvement in diabetic autonomic neuropathy.