Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Appropriate background correction for DTPA aerosol clearance

G R Mason1, A M Peters, M J Myers

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, United Kingdom.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Current dilemmas on the transmission of hepatitis E virus].

Nederlands tijdschrift voor geneeskunde·2017
Same author

Relationships of body habitus and SUV indices with signal-to-noise ratio of hepatic (18)F-FDG PET.

European journal of radiology·2016
Same author

The appropriate whole-body index on which to base standardized uptake value in 2-deoxy-2-[(18)F]fludeoxyglucose PET.

The British journal of radiology·2015
Same author

Adjuvant taxanes and the development of breast cancer-related arm lymphoedema.

The British journal of surgery·2015
Same author

Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer.

The British journal of surgery·2015
Same author

A constitutional predisposition to breast cancer-related lymphoedema and effect of axillary lymph node surgery on forearm muscle lymph flow.

Breast (Edinburgh, Scotland)·2014
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

This study found that using the liver or cranium for background correction improves the accuracy of lung injury detection using 99mTc-diethylenetriamine pentaacetic acid (DTPA) aerosol clearance measurements. This method provides a more precise assessment of lung function compared to traditional thigh correction.

Area of Science:

  • Nuclear medicine
  • Pulmonary physiology
  • Medical imaging

Background:

  • Pulmonary clearance rate measurement using 99mTc-diethylenetriamine pentaacetic acid (DTPA) aerosol is crucial for detecting lung injury.
  • Conventional background subtraction using the thigh has limitations due to differing tissue composition compared to the lung.

Purpose of the Study:

  • To evaluate alternative background regions (liver and cranium) for more accurate pulmonary signal correction.
  • To compare the effectiveness of liver, cranium, and thigh for background subtraction in DTPA lung clearance studies.

Main Methods:

  • Intravenous injection of 99mTc-DTPA for background calibration.
  • Gamma camera monitoring of time-activity curves over the lung, liver, and cranium.
  • Comparison of lung clearance rates calculated with different background subtraction methods.

Related Experiment Videos

Main Results:

  • Liver and cranium showed time-activity curves that superimposed well with the lung, unlike the thigh.
  • Lung clearance rates using liver or cranium background were more accurate and revealed multiexponential curves, unlike thigh correction.
  • Thigh correction resulted in monoexponential or upwardly convex curves, obscuring true lung clearance dynamics.

Conclusions:

  • Liver and cranium are superior background regions for 99mTc-DTPA lung clearance studies.
  • Accurate background subtraction is essential for identifying the true shape of lung clearance curves.
  • This improved method allows for better monitoring of interventions affecting lung clearance.