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Higher risk of preeclampsia in the polycystic ovary syndrome. A case control study
M J de Vries1, G A Dekker, J Schoemaker
1Department of Obstetrics and Gynaecology, Free University Hospital of Amsterdam, The Netherlands.
Objective:
To determine whether the risk of pregnancy-induced hypertensive disorders (PIHD) is higher in patients with the polycystic ovary syndrome (PCOS) than in non-PCOS controls, matched for age and parity.
Study Design:
Retrospective analysis of eighty-one patients with PCOS, consecutively becoming pregnant during a seven-year period. Each PCOS-patient was matched for age and parity with one control patient. Chi-squared, Mann-Whitney or Fisher's exact-tests were used for statistical analysis.
Results:
Overall incidence of PIHD was similar in both study groups. However, incidence of preeclampsia was significantly higher in patients with PCOS than in controls (P = 0.02). This higher incidence can not be explained by body mass index, endocrine profile before pregnancy, induction of ovulation or treatment regimens.
Conclusions:
PCOS-patients are at a significantly higher risk for preeclampsia than non-PCOS controls.
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