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Updated: Aug 15, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Anaplastic thyroid carcinoma with osteoclast-like giant cells]
B S Serezhin1, N M Anichkov, Iu L Avdeenko
1I.I. Mechnikov State Medical Academy, Sanct-Petersburg.
Arkhiv Patologii
|March 4, 1998
Summary
A rare, rapidly growing thyroid tumor in a 70-year-old female contained three distinct histological components. Osteoclast-like cells within the tumor showed immunoreactive thyroglobulin, suggesting a unique thyroid tumor origin.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Thyroid tumors can exhibit diverse histological patterns.
- Rapidly growing thyroid masses require thorough investigation.
Observation:
- A case of a rapidly growing thyroid tumor in a 70-year-old female is presented.
- Histological examination revealed three distinct structures: follicular adenoma, follicular-solid adenoma, and a poorly differentiated component.
- The poorly differentiated area contained osteoclast-like giant cells.
Findings:
- Osteoclast-like cells within the thyroid tumor demonstrated immunoreactivity for thyroglobulin.
- This finding suggests a potential origin or differentiation pathway related to thyroid follicular cells.
Implications:
- The presence of thyroglobulin-positive giant cells offers insights into the cellular origin and behavior of rare thyroid neoplasms.
- Further research is warranted to elucidate the pathogenesis of these unique giant cells in thyroid tumors.
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