[Attenuation of the efficacy of vasoconstrictive effects in rats after a 3-week suspension]

Male Wistar rats were maintained suspended by the skin of posterior third of the back for three weeks. Constrictive reactions to norepinephrine and irritation of sympathetic nerves were studied with hindlimb vessels perfused with physiological solution at constant pressure. Perfusion pressure was stabilized at 40, 80, and 120 mmHg. During complete relaxation of the vascular smooth muscles the volumetric rate of perfusate flow in experimental animals was reduced comparing with their controls. This implies narrowing of the lumen in resistive vessels caused by suspension. Following suspension, reaction of rat's nerves to irritation was markedly lower than in the control at all levels of pressure. At 40 mmHg vessels of the suspended rats were more sensitive to norepinephrine; however, at 80 and 120 mmHg vascular sensitivity to the agent was reduced in the test group vs. the control. Suppression of the reactivity of hindlimb vessels to the constrictive agents may be one of the causes of failure of mechanisms of blood redistribution following prolonged gravitational deloading.