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Related Experiment Videos

Occult pregnancy. A pilot study

S K Bloch

    Obstetrics and Gynecology
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Early pregnancy loss, termed occult pregnancy, can be detected through elevated luteinizing hormone levels. This finding suggests a pregnancy occurred even with a normal menstrual period following.

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    Area of Science:

    • Reproductive Endocrinology
    • Early Pregnancy Detection

    Background:

    • Occult pregnancy is defined as a pregnancy aborting so early that no clinical suspicion arises.
    • Diagnosis is challenging due to minimal or absent symptoms, often presenting as a slight menstrual delay.

    Purpose of the Study:

    • To investigate the incidence of occult pregnancy in Clomid-induced ovulatory cycles.
    • To determine if hormonal markers can indicate these early, unsuspected pregnancies.

    Main Methods:

    • Studied 16 Clomid-induced ovulatory cycles with biphasic temperature charts and hyperthermic phases ≥ 12 days.
    • Measured serum luteinizing hormone (LH) values in the late luteal phase.
    • Assessed LH values for elevation indicating cross-reactivity with human chorionic gonadotropin (hCG).

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    Main Results:

    • Six out of 16 cycles (37.5%) showed significantly elevated LH levels (>3 standard deviations).
    • These elevated LH levels suggest cross-reactivity with hCG, indicating an occult pregnancy.
    • All participants experienced clinically normal menstrual periods 12 hours to 6 days later.

    Conclusions:

    • Elevated LH levels in the late luteal phase can serve as an indicator of occult pregnancy.
    • This hormonal marker allows for the detection of pregnancies that would otherwise go unnoticed.
    • Further research is needed to explore the clinical significance and management of these early pregnancy losses.