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[Basaliomas with invasion of bone: problems and prognosis]
1Klinik für Mund-, Kiefer-Gesichtschirurgie, Martin-Luther-Universität, Halle-Wittenberg.
Mund-, Kiefer- Und Gesichtschirurgie : MKG
|February 1, 1997
Summary
Basal cell carcinoma surgery offers excellent cure rates. However, bone infiltration significantly worsens prognosis, with recurrence rates reaching 90% even for primary tumors.
Area of Science:
- Oncology
- Surgical Pathology
- Head and Neck Surgery
Context:
- Basal cell carcinoma (BCC) is the most common skin cancer.
- Orofacial BCC can present unique challenges, particularly with deeper tissue invasion.
- Surgical management is the primary treatment modality for BCC.
Purpose:
- To analyze the recurrence rates of orofacial basal cell carcinomas with bony involvement.
- To identify prognostic factors influencing cure rates in these specific cases.
- To compare the impact of bony infiltration versus positive resection margins on BCC recurrence.
Summary:
- While surgical management yields excellent cure rates for basal cell carcinoma (BCC), bony involvement adversely affects prognosis.
- In this series, only 0.5% of orofacial BCCs involved bone; however, these 12 cases demonstrated high recurrence rates (60% for primary, 90% for recurrent tumors).
- Kaplan-Meier analysis suggests an expected 10-year recurrence rate of approximately 90% for BCC with bone infiltration, highlighting bone invasion as a critical factor, more so than positive surgical margins.
Impact:
- Findings underscore the poor prognosis associated with bony infiltration in orofacial BCC.
- Highlights the need for aggressive surgical approaches and potentially adjuvant therapies for BCC invading bone.
- Emphasizes that bony infiltration is a more significant predictor of recurrence than margin status in orofacial BCC.