Criteria for evaluating protein structures derived from comparative modeling
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Updated: Oct 30, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
C Venclovas1, A Zemla, K Fidelis
1Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California, USA.
Abstract:
Following the first experiment for the Critical Assessment of methods for protein Structure Prediction (CASP1), numerical criteria were devised to analyze the performance of prediction methods. We report here the criteria for comparative modeling, and how effective they were in CASP2. These criteria are intended to evolve into a set of numerical measures that provide a comprehensive assessment of the quality of a structure produced by comparative modeling, and provide a means of investigating which modeling methods are most effective, so as to establish where future effort may be most productively applied.
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