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Pseudoexfoliation syndrome and secondary cataract
1University of Erlangen-Nürnberg, Department of Ophthalmology, Erlangen, Germany.
The British Journal of Ophthalmology
|March 5, 1998
Summary
Pseudoexfoliation syndrome increases the risk of secondary cataract after cataract surgery. This complication, defined as posterior capsule opacification, occurred more frequently in patients with pseudoexfoliation (PEX) syndrome.
Area of Science:
- Ophthalmology
- Surgical Complications
- Intraocular Lens Implantation
Background:
- Pseudoexfoliation (PEX) syndrome is linked to blood-aqueous barrier dysfunction.
- This dysfunction may contribute to secondary cataract formation post-surgery.
Purpose of the Study:
- To investigate the association between PEX syndrome and secondary cataract development after cataract extraction.
- To determine if PEX syndrome is a risk factor for secondary cataract.
Main Methods:
- Historical cohort study of 197 patients undergoing extracapsular cataract extraction.
- Comparison of secondary cataract rates between eyes with and without PEX syndrome.
- Kaplan-Meier and Cox regression analyses used for statistical evaluation.
Main Results:
- Secondary cataract occurred in 35% of eyes within 24 months.
- Eyes with PEX syndrome had a significantly higher incidence of secondary cataract (45%) compared to those without (24%).
- Eyes with diabetes mellitus showed a lower frequency of secondary cataract.
Conclusions:
- Pseudoexfoliation syndrome is associated with a higher frequency of secondary cataract post-cataract surgery.
- This finding highlights PEX syndrome as a potential risk factor for this complication.