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Radiotherapy for Kimura's disease: the optimum dosage
M Hareyama1, A Oouchi, H Nagakura
1Department of Radiology, Sapporo Medical University, School of Medicine, Japan.
Summary
Radiotherapy effectively treats Kimura's disease, with optimal local control achieved using 26-30 Gy. This dosage is recommended regardless of tumor size, suggesting radiotherapy as a primary treatment modality.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Kimura's disease is a rare benign condition characterized by eosinophilic infiltration.
- It typically affects the head and neck region, often involving salivary glands and lymph nodes.
Purpose of the Study:
- To determine the optimal radiation dosage for treating Kimura's disease.
- To evaluate the efficacy of radiotherapy in achieving local control for Kimura's disease.
Main Methods:
- Retrospective analysis of 20 patients with Kimura's disease treated with radiotherapy.
- Dosages ranged from 20 to 44 Gy, with a focus on residual or recurrent tumors.
- Eosinophil counts and local control rates were assessed post-treatment.
Main Results:
- All patients showed a marked response in tumor size after radiotherapy.
- Local control was achieved in 74.1% of lesions.
- Dosages of 26-30 Gy and >30 Gy resulted in higher local control rates (90.0% and 92.3%) compared to <=25 Gy (25.0%).
Conclusions:
- Radiotherapy is an effective treatment for Kimura's disease.
- An optimal radiation dosage of 26-30 Gy is recommended for effective local control.
- Minimally invasive biopsy is suggested, avoiding extensive surgery.