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[The effect of the delta sleep-inducing peptide on NMDA-induced seizure activity in rats]
A A Shandra1, L S Godlevskiĭ, A I Brusentsov
1State Medical University, Odessa, Ukraine.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|March 6, 1998
Abstract:
The ED100 of the NMDA inducing clonic seizures (0.53 mcg) or tonic extension of forelimbs (5.02 mcg) increased their efficiency 2.3-fold and 4.46-fold, resp., due to the delta-sleep-inducing peptide administration in rats. The data obtained suggests a neuroprotective effect of the peptide on agonists of excitatory amino acid receptors action.