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Isolated pancreatic extramedullary hematopoiesis
S Crider1, A Kroszer-Hamati, K Krishnan
1Department of Internal Medicine, James H. Quillen College of Medicine and VA Medical Centre, East Tennessee State University, Johnson City 37614-0622, USA.
Acta Haematologica
|March 7, 1998
Summary
This study reports the first documented case of pancreatic extramedullary hematopoiesis (EMH) in a patient with lung cancer and an atypical myeloproliferative disorder. The condition involved abnormal blood cell production within the pancreas, distinct from typical presentations.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Extramedullary hematopoiesis (EMH) is the formation of blood cells outside of the bone marrow.
- While EMH can occur in various organs, its presence in the pancreas is exceptionally rare.
- This case investigates EMH in the pancreas in the context of lung cancer and myeloproliferative disorders.
Observation:
- A 59-year-old male patient presented with lung cancer, leukocytosis, and thrombocytosis.
- Physical examination revealed no peripheral lymphadenopathy or hepatosplenomegaly.
- Imaging and subsequent analysis identified extramedullary hematopoiesis localized to the pancreas.
Findings:
- The pancreatic EMH was associated with an 'atypical' myeloproliferative disorder.
- Genetic studies for the Philadelphia chromosome and bcr-abl fusion product were negative, ruling out common causes like CML.
- This represents the first reported instance of isolated pancreatic extramedullary hematopoiesis in medical literature.
Implications:
- This case expands the known spectrum of extramedullary hematopoiesis locations.
- It highlights the importance of considering rare pancreatic pathologies in patients with hematological abnormalities and cancer.
- Further research may elucidate the specific mechanisms and clinical significance of pancreatic EMH.