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Related Experiment Videos

Periapical abscesses: causal bacteria and antibiotic sensitivity

P D Goumas1, S S Naxakis, D A Papavasiliou

  • 1Dept of ENT, University Hospital of Patras, Greece.

Journal of Chemotherapy (Florence, Italy)
|March 10, 1998
PubMed
Summary

Periapical abscesses frequently harbor anaerobic bacteria, necessitating antibiotic choices that target these microbes. Nitroimidazoles, chloramphenicol, and clindamycin show broad-spectrum activity against these anaerobes.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dental Infections

Background:

  • Periapical abscesses are common dental infections.
  • Understanding the microbial flora is crucial for effective treatment.

Purpose of the Study:

  • To identify aerobic and anaerobic bacteria in periapical abscesses.
  • To assess the antibiotic susceptibility of isolated microorganisms.

Main Methods:

  • Pus cultures were obtained from 52 patients diagnosed with periapical abscesses.
  • Aerobic and anaerobic bacteria were identified and quantified.
  • Antibiotic susceptibility testing was performed on isolated anaerobic species.

Main Results:

  • A high prevalence of anaerobic bacteria was observed (122 isolates vs. 42 aerobes).

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  • Mixed infections were most common (75%).
  • Bacteroides group, Peptostreptococcus, and Peptococcus spp. were predominant anaerobes.
  • Streptococci and staphylococci were the most common aerobes.
  • Nitroimidazole derivatives, chloramphenicol, and clindamycin demonstrated broad-spectrum activity against anaerobes.
  • Ofloxacin showed effectiveness among newer quinolones.

    • Conclusions:

    • Anaerobic bacteria play a significant role in periapical abscesses.
    • Empirical antibiotic therapy should consider the high prevalence and susceptibility patterns of anaerobic organisms.
    • Nitroimidazoles, chloramphenicol, and clindamycin remain effective treatment options.