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Related Experiment Videos

Emerging issues in blood safety

M Chamberland1, R F Khabbaz

  • 1Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Infectious Disease Clinics of North America
|March 12, 1998
PubMed
Summary
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Blood transfusion safety has improved through better donor screening and viral inactivation, significantly reducing risks from hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency viruses (HIV). Ongoing vigilance is needed for emerging infectious threats and bacterial contamination.

Area of Science:

  • Infectious Diseases
  • Transfusion Medicine
  • Public Health

Background:

  • Transfusion-transmitted infections (TTIs) pose a significant public health risk.
  • Advances in donor screening and viral inactivation have reduced risks from known pathogens like HBV, HCV, and HIV.
  • Emerging infectious agents and novel transmission routes present ongoing challenges to blood safety.

Purpose of the Study:

  • To review the current state of transfusion safety regarding infectious agents.
  • To highlight progress in mitigating transfusion-associated infections.
  • To identify emerging threats and areas requiring further assessment in transfusion medicine.

Main Methods:

  • Review of literature on transfusion safety practices.
  • Analysis of advancements in donor selection and testing protocols.

Related Experiment Videos

  • Examination of viral inactivation techniques for plasma-derived products.

    • Main Results:

    • Significant reductions in transfusion-associated HBV, HCV, and HIV have been achieved.
    • Concerns persist regarding emerging infections such as specific HIV strains, nonenveloped viruses, and prions.
    • Bacterial contamination remains a notable cause of transfusion reactions requiring ongoing monitoring.

    Conclusions:

    • Current safety measures have substantially decreased transfusion risks from common viral pathogens.
    • Continuous evaluation of donor screening, testing, and pathogen reduction technologies is crucial.
    • Addressing emerging infectious threats and bacterial contamination is essential for maintaining blood product safety.