Related Experiment Video
Updated: Aug 15, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Resinifying therapy in endodontics. II--Histological and bacteriological evaluation
Summary
Resinifying therapy shows promise in root canal treatment, effectively combating microorganisms and penetrating dentinal tubules. While periapical tissue repair takes time, clinical function remains positive, indicating a viable therapeutic approach.
Area of Science:
- Endodontics
- Dental Materials Science
- Histopathology
Background:
- Root canal treatment aims to eliminate intraradicular infection and seal the root canal system.
- Periapical inflammation and infection pose challenges in endodontic therapy.
- Novel materials are continuously investigated for improved endodontic outcomes.
Purpose of the Study:
- To histologically evaluate the periapical tissue response to resin resorcinol.
- To assess the antibacterial efficacy of resin resorcinol against common oral microorganisms.
- To determine the penetration depth of resin resorcinol into dentinal tubules.
Main Methods:
- Histological examination of periapical tissues in rabbits and rats after 12 days.
- Bacteriological analysis of resin resorcinol.
- Microscopic evaluation of resin penetration in human teeth.
Main Results:
- Significant presence of lymphocytes and macrophages, with granuloma formation, indicating prolonged resin presence.
- Resin penetration observed up to three-fourths the length of dentinal tubules.
- Resin resorcinol demonstrated effectiveness against eight common microorganisms.
Conclusions:
- Resinifying therapy exhibits antimicrobial properties and good dentinal tubule penetration.
- Periapical tissue healing may require an extended period, but clinical tooth function is maintained.
- Resinifying therapy presents an effective and economical option for root canal treatment.
