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Procedure for studying commutability validated by biological variation

C Ricós1, R Juvany, C V Jiménez

  • 1Biochemistry Department, Hospital General Vall d'Hebron, Barcelona, Spain. cricos@hg.vhebron.es

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 12, 1998
PubMed
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Evaluating material commutability in laboratory medicine is crucial. Passing-Bablok regression with confidence intervals is recommended for reliable and simple commutability assessment, validated by biological variation.

Area of Science:

  • Laboratory medicine
  • Clinical chemistry
  • Biomarker analysis

Background:

  • Commutability evaluations are essential for ensuring accurate patient sample results in laboratory medicine.
  • Existing quantitative approaches for assessing material commutability show discrepancies.
  • Standardization of commutability evaluation procedures is vital due to method-specific material responses.

Purpose of the Study:

  • To validate a criterion for acceptability in determining material commutability.
  • To compare different statistical methods for assessing material commutability.
  • To identify the most reliable method for evaluating commutability of stabilized materials.

Main Methods:

  • Applied three methods for commutability assessment: confidence interval (alpha = 0.05), +/- 2s(yx) formula, and biological variation limit.

Related Experiment Videos

  • Utilized creatinine results from 31 stabilized materials and serum samples analyzed across seven instruments.
  • Compared results against a reference method for creatinine analysis.

    • Main Results:

    • Confidence interval and biological variation limits agreed on identifying commutable materials across a wide concentration range.
    • The +/- 2s(yx) method proved excessively permissive at normal and low creatinine concentration levels.
    • Passing-Bablok regression with a 0.05 confidence interval demonstrated reliability and ease of calculation.

    Conclusions:

    • Passing-Bablok regression with confidence intervals is recommended for commutability studies in laboratory medicine.
    • This method provides reliable and easily calculable commutability assessments.
    • Validation by biological variation ensures the dependability of the results.