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Choriocapillary changes and hyperfluorescence on indocyanine green angiography
1Department of Ophthalmology, Osaka City University Medical School, Japan.
Summary
Bright fluorescence on indocyanine green (ICG) angiography correlates with pathological changes in choriocapillaris (CC) endothelial cells. This relationship allows ICG angiography to assess CC endothelial cell permeability in various conditions.
Area of Science:
- Ophthalmology
- Histology
- Angiography
Background:
- The choriocapillaris (CC) is crucial for retinal health.
- Pathological changes in the CC can lead to vision impairment.
- Understanding CC alterations is key to diagnosing and managing retinal diseases.
Purpose of the Study:
- To investigate the correlation between choriocapillaris pathological changes and bright fluorescence observed during indocyanine green (ICG) angiography.
- To establish ICG angiography as a tool for evaluating CC endothelial cell permeability.
Main Methods:
- An animal model was utilized to induce chorioretinal lesions.
- Sodium iodate was injected at varying time points (3 hours, 24 hours, 7 days, 14 days) prior to analysis.
- ICG angiographic findings were systematically compared with histological examinations.
Main Results:
- Bright fluorescence on ICG angiography was observed as early as 3 hours post-injection, intensifying by 24 hours.
- Histology revealed progressive damage to CC endothelial cells, including cytoplasmic changes, fenestral loss, and detachment from the basement membrane.
- By 14 days, ICG fluorescence normalized, and histological examination showed near-normal CC endothelial cell structure.
Conclusions:
- A strong relationship exists between choriocapillaris endothelial cell pathology and bright fluorescence on ICG angiography.
- ICG angiography can serve as a valuable clinical method for assessing the permeability of CC endothelial cells to larger molecules.
- These findings enhance our understanding of retinal vascular integrity and diagnostic capabilities.