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Effect of nitric oxide on poliovirus infection of two human cell lines
J A López-Guerrero1, L Carrasco
1Centro de Biología Molecular, CSIC-UAM, Spain. JALOPEZ@TRASTO.CBM.UAM.ES
Journal of Virology
|March 14, 1998
Abstract:
The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, pretreatment with the nitric oxide donor glycerine trinitrate lengthened the course of poliovirus infection.