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[Perfusion-MRI in cerebral infarct]
1Abteilung für Neuroradiologie, Universität des Saarlandes.
Purpose:
To investigate the hemodynamic changes in patients with acute cerebral stroke by perfusion MRI.
Material And Methods:
In 12 patients with acute stroke in the territory of the middle cerebral artery, perfusion MRI was performed. Peak time, mean transit time, regional cerebral blood volume and regional cerebral blood flow were calculated in the infarction, the peri-infarction area and the contralateral hemisphere.
Results:
In the infarction the mean blood flow was 29 ml/100 g/min, compared to about 40 ml/100 g/min in the peri-infarction area and the contralateral hemisphere. In two patients increased cortical blood flow was found in the infarction due to luxury perfusion. The cerebral blood volume was reduced in the infarction, but significantly increased, to 7.3 ml/100 g, in the peri-infarction tissue.
Conclusion:
Perfusion MRI allows one to differentiate various patterns of perfusion disorders in patients with acute cerebral stroke. The resulting data may be helpful in describing the pathophysiologic mechanisms of compensation.
Insights
Perfusion MRI reveals distinct hemodynamic changes in acute cerebral stroke patients. This technique helps understand compensatory mechanisms in stroke by analyzing blood flow and volume.
Area of Science:
- Neuroimaging
- Radiology
- Cerebrovascular Diseases
Context:
- Acute cerebral stroke impacts brain hemodynamics.
- Understanding these changes is crucial for diagnosis and treatment.
- Perfusion MRI offers detailed insights into cerebral blood flow and volume.
Purpose:
- To investigate hemodynamic changes in acute cerebral stroke patients using perfusion MRI.
- To quantify regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV).
- To analyze perfusion parameters in the infarct core, peri-infarction zone, and contralateral hemisphere.
Summary:
- Perfusion MRI was performed on 12 acute middle cerebral artery stroke patients.
- Calculated parameters included mean transit time, rCBF, and rCBV.
- Results showed reduced rCBF and rCBV in the infarct, with increased rCBV in peri-infarct tissue. Luxury perfusion was observed in two cases.
Impact:
- Perfusion MRI effectively differentiates perfusion disorders in acute stroke.
- Findings aid in elucidating pathophysiological compensation mechanisms.
- Provides quantitative data for clinical assessment and research.