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Related Concept Videos

Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
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Asymmetric Lipid Bilayer01:35

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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What are Lipids?01:38

What are Lipids?

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Overview
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What are Lipids?01:31

What are Lipids?

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Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
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Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
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Zinc diffusion through lipid bilayers

S E Pattison1, S Telles, S Friar

  • 1Department of Chemistry, Ball State University, Muncie, Indiana 47306, USA.

Archives of Biochemistry and Biophysics
|March 17, 1998
PubMed
Summary
This summary is machine-generated.

Lipid oxidation significantly accelerates zinc diffusion across liposome bilayers, approaching cellular transport rates. This finding highlights the impact of lipid peroxidation on zinc ion permeability.

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Area of Science:

  • Biochemistry
  • Membrane Biophysics
  • Lipid Chemistry

Background:

  • Zinc ions are crucial for cellular functions.
  • Liposome bilayers are model systems for biological membranes.
  • Understanding ion transport across membranes is vital for cell biology.

Purpose of the Study:

  • To investigate the effect of phosphatidylcholine properties on zinc diffusion across liposome bilayers.
  • To determine the relationship between lipid oxidation and zinc ion permeability.
  • To compare liposomal zinc diffusion rates with cellular zinc transport.

Main Methods:

  • Formation of small unilamellar vesicles from phosphatidylcholines.
  • Measurement of zinc diffusion using the metallochromic indicator antipyrylazo III.
  • Quantification of lipid oxidation via thiobarbituric acid test and conjugate diene spectrophotometry.

Main Results:

  • Zinc diffusion rate constant increased linearly with zinc concentration.
  • The second-order rate constant was independent of zinc concentration but sensitive to lipid properties.
  • Lipid oxidation, not membrane fluidity, strongly correlated with increased zinc diffusion rates.
  • Stimulated zinc diffusion approached rates observed in hepatocyte zinc transport.

Conclusions:

  • Lipid oxidation is a key factor enhancing zinc diffusion across liposome bilayers.
  • This study provides insights into mechanisms potentially regulating zinc transport in biological systems.
  • Oxidative stress may significantly impact cellular zinc homeostasis.