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[Oxidative modification of monoamine oxidase]
1Institute of Biomedical Chemistry, Moscow, Russia.
Voprosy Meditsinskoi Khimii
|March 21, 1998
Summary
Oxidative modification of monoamine oxidases (MAO) alters enzyme function and inhibitor sensitivity. This modification, involving SH group oxidation, is observed in various diseases, but its biological role needs further study.
Area of Science:
- Biochemistry
- Enzymology
Context:
- Monoamine oxidases (MAO) play crucial roles in neurotransmitter metabolism.
- Oxidative modification of MAO has been recognized for over 30 years.
Purpose:
- To summarize the phenomenon of oxidative modification of MAO.
- To highlight the mechanistic aspects and implications of MAO modification.
Summary:
- Oxidative modification of MAO leads to changes in substrate specificity and inhibitor sensitivity.
- The mechanism involves the oxidation of enzyme sulfhydryl (SH) groups.
- This modification also increases susceptibility to limited proteolysis.
Impact:
- MAO modification is observed in numerous pathological conditions.
- Further research is needed to fully elucidate the biological significance of MAO oxidative modification.