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Risk factors for hepatotoxicity induced by antituberculosis drugs
F M Devoto1, C González, R Iannantuono
1Department of Pharmacology, Faculty of Medicine, University of Buenos Aires, Argentina. flamar@mail.interserver.com.ar
Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [De] La Asociacion Latinoamericana De Farmacologia
|January 1, 1997
Summary
Antituberculosis treatment can cause liver injury. Alcoholism, HIV infection, and female sex significantly increase the risk of drug-induced hepatotoxicity during tuberculosis treatment.
Area of Science:
- Hepatology
- Infectious Diseases
- Pharmacology
Background:
- Hepatotoxicity is a significant concern during antituberculosis treatment.
- Identifying risk factors is crucial for patient safety and treatment management.
Purpose of the Study:
- To evaluate risk factors associated with antituberculosis treatment-induced hepatotoxicity.
- To determine the impact of alcoholism, HIV infection, sex, and age on liver injury during treatment.
Main Methods:
- Retrospective study of 456 patients undergoing antituberculosis therapy.
- Analysis included univariate methods, stratified analysis, and multiple logistic regression.
- Investigated associations between hepatotoxicity and risk factors: age, sex, alcoholism, and HIV infection.
Main Results:
- Hepatotoxicity observed in 9.86% of patients.
- Alcoholism showed a strong association (OR=17.31, p<0.001).
- HIV infection (OR=3.23, p=0.003) and female sex (OR=2.44, p=0.011) were also significant risk factors.
- Age was not significantly associated with hepatotoxicity.
Conclusions:
- Alcoholism, HIV infection, and female sex are significant risk factors for antituberculosis treatment-induced hepatotoxicity.
- These findings aid in identifying high-risk patients and implementing preventative strategies.