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Alcohol and mortality in middle-aged men from eastern France

S C Renaud1, R Guéguen, J Schenker

  • 1Institut National pour la Santé et la Recherche Médicale (INSERM), Unit 330, Bordeaux, France.

Epidemiology (Cambridge, Mass.)
|March 21, 1998
PubMed
Summary

Moderate wine consumption, defined as 2-5 glasses daily, was linked to a significant reduction in all-cause mortality among middle-aged men. This finding held true for both smokers and non-smokers, suggesting a protective effect of moderate wine intake.

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Area of Science:

  • Epidemiology
  • Public Health
  • Nutritional Science

Background:

  • Wine consumption is a prevalent habit in many cultures.
  • Previous studies have suggested potential health benefits and risks associated with alcohol intake.
  • Understanding the specific impact of wine on mortality is crucial for public health guidelines.

Purpose of the Study:

  • To prospectively evaluate the association between wine consumption and all-cause mortality.
  • To investigate the relationship between different levels of alcohol intake from wine and mortality risks.
  • To examine if smoking status modifies the effect of wine drinking on mortality.

Main Methods:

  • A prospective cohort study of 34,014 middle-aged men in Eastern France.
  • Data collected via questionnaire on lifestyle factors including drinking habits, smoking, physical activity, and education.

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  • Mortality assessed over a 10-15 year follow-up period using Cox proportional hazard models.

    • Main Results:

    • Moderate wine intake (22-54 gm/day, approx. 2-5 glasses) was associated with a reduced relative risk (RR) of all-cause death (RR=0.70-0.76).
    • This mortality reduction was attributed to fewer deaths from cardiovascular disease and cancer.
    • High alcohol consumption (above 128 gm/day) was linked to an increased RR of death (RR=1.37).

    Conclusions:

    • Moderate wine consumption is associated with a significant reduction in all-cause mortality.
    • The observed protective effect on mortality is independent of smoking status.
    • Excessive alcohol intake from wine increases the risk of mortality.