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Delayed-type hypersensitivity to contact allergens in psoriasis. A clinical evaluation
F Heule1, G J Tahapary, C R Bello
1Department of Dermato-Venereology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
Contact Dermatitis
|March 20, 1998
Summary
Patch testing in psoriasis patients revealed a high 68% contact allergy rate, particularly to tars, nickel sulfate, perfume, and balsam of Peru. These findings suggest a significant link between psoriasis and contact allergies.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Contact allergy is a common cause of skin reactions.
- The relationship between psoriasis and contact allergy requires further investigation.
Purpose of the Study:
- To investigate the prevalence of contact allergy in hospitalized patients with psoriasis using patch testing.
- To identify common allergens triggering reactions in this patient group.
Main Methods:
- Patch testing was performed on 47 selected psoriasis patients.
- Exclusion criteria included active lesions, and use of specific medications or therapies.
- Standard and extended allergen series were used based on patient history.
Main Results:
- The overall positive rate for contact allergy was 68%.
- Tars, nickel sulfate, perfume, and balsam of Peru were frequently identified allergens.
- This positive rate is higher than previously reported in similar studies.
Conclusions:
- Patch testing is a valuable tool for detecting contact allergy in psoriasis patients.
- A significant proportion of psoriasis patients may have underlying contact allergies.
- Further research into the mechanisms underlying these findings is warranted.