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Related Experiment Videos

Prolactin pulsatile characteristics in postmenopausal women

L Katznelson1, P N Riskind, V C Saxe

  • 1General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. katznelsonl@a1.mgh.harvard.edu

The Journal of Clinical Endocrinology and Metabolism
|March 20, 1998
PubMed
Summary

Menopause alters prolactin (PRL) secretion dynamics, making them similar to men. Cycling women show higher PRL levels, suggesting estrogen influences PRL pulsatile secretion across genders.

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Hormone Secretion Dynamics

Background:

  • Pulsatile prolactin (PRL) secretion exhibits diurnal variation, peaking in the evening during sleep.
  • The effects of menopause on PRL pulsatile dynamics remain largely uncharacterized.

Purpose of the Study:

  • To investigate and characterize diurnal PRL pulsatile secretion patterns in postmenopausal women.
  • To compare these patterns with those of men and cycling women.

Main Methods:

  • Frequent venous sampling (every 10 min) over 24 hours to measure serum PRL in 7 postmenopausal women, 8 men, and 22 cycling women.
  • Standard thyrotropin-releasing hormone (TRH) tests administered to assess PRL response.

Main Results:

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  • PRL pulse characteristics were similar between postmenopausal women and men.
  • Cycling women exhibited significantly higher mean serum PRL levels and pulse frequency than postmenopausal women and men.
  • Higher PRL levels and pulse frequency were observed during nighttime compared to daytime across all groups.

    • Conclusions:

    • PRL pulse dynamics differ significantly between postmenopausal and cycling women, indicating a potential role for endogenous estrogen.
    • Pulsatile PRL secretion patterns are comparable between postmenopausal women and men, suggesting estrogen modulates PRL dynamics across genders.