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Intracranial aneurysms in identical twins
1Department of Neurosurgery, Osaka City General Hospital, Miyakojima, Japan.
Surgical Neurology
|March 21, 1998
Summary
Identical twins experiencing subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms suggest a higher familial risk. Screening asymptomatic twins with affected siblings is recommended.
Area of Science:
- Neurology
- Genetics
- Vascular Surgery
Background:
- Familial intracranial aneurysms are recognized, but cases in identical twins are rare.
- Intracranial aneurysms are abnormal bulges in brain blood vessels.
Observation:
- A 46-year-old woman presented with subarachnoid hemorrhage (SAH) caused by a ruptured aneurysm.
- Her identical twin sister had a similar event (SAH from a ruptured aneurysm) at age 36.
- Both sisters underwent successful treatment for their ruptured aneurysms.
Findings:
- The occurrence of intracranial aneurysms may be elevated in individuals whose identical twin has a diagnosed aneurysm.
- This case highlights a potential genetic predisposition or shared environmental factors.
Implications:
- Consider screening for intracranial aneurysms in asymptomatic individuals who have an identical twin with a history of aneurysmal subarachnoid hemorrhage.
- Early detection through screening may improve outcomes and prevent future ruptures.