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Cutaneous leishmaniasis: iso-enzyme characterisation of Leishmania tropica

M A Rab1, L al Rustamani, R A Bhutta

  • 1Health Services Academy, Ministry of Health and National Institute of Health, Islamabad.

JPMA. the Journal of the Pakistan Medical Association
|March 25, 1998
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...