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Localized scleroderma

D L Tuffanelli1

  • 1University of California, San Francisco 94108, USA.

Seminars in Cutaneous Medicine and Surgery
|March 25, 1998
PubMed
Summary
This summary is machine-generated.

Localized scleroderma presents in three subtypes: morphea, linear, and generalized forms. While plaque morphea has a good prognosis, linear and generalized types may have poorer outcomes and limited treatment effectiveness.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Localized scleroderma encompasses morphea, linear scleroderma, and generalized morphea.
  • Plaque morphea generally presents with a favorable prognosis.
  • Variants like guttate morphea and atrophoderma of Pasini and Pierini are recognized.

Purpose of the Study:

  • To outline the classification and clinical characteristics of localized scleroderma subtypes.
  • To discuss the prognostic factors and therapeutic challenges associated with each subtype.
  • To differentiate generalized morphea from systemic scleroderma.

Main Methods:

  • Review of existing literature on localized scleroderma classification and subtypes.
  • Analysis of clinical presentations, serological associations, and prognoses.

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  • Comparison of generalized morphea with systemic scleroderma.

    • Main Results:

    • Morphea, linear scleroderma, and generalized morphea are distinct subtypes.
    • Linear scleroderma, particularly affecting extremities or face, shows serological abnormalities and poor cosmetic/functional prognosis.
    • Generalized morphea is challenging to distinguish from systemic scleroderma, but progression is rare.

    Conclusions:

    • Localized scleroderma subtypes exhibit varied prognoses and clinical features.
    • Effective therapies for localized scleroderma remain limited.
    • Distinguishing generalized morphea from systemic scleroderma is crucial, with uncommon progression to systemic disease.