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Related Experiment Videos

Iron in prenatal multivitamin/multimineral supplements. Bioavailability

E B Dawson1, R Dawson, J Behrens

  • 1Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555, USA.

The Journal of Reproductive Medicine
|March 26, 1998
PubMed
Summary

Iron absorption from prenatal supplements varies significantly due to ingredient combinations, not just iron content. Some formulations provide less than the recommended daily iron intake.

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Area of Science:

  • Nutritional Science
  • Pharmacology
  • Maternal Health

Background:

  • Prenatal multivitamins are crucial for maternal and fetal health.
  • Iron is a key nutrient often supplemented during pregnancy.
  • Variability in supplement formulations may impact nutrient bioavailability.

Purpose of the Study:

  • To assess iron bioavailability from four popular prenatal supplements.
  • To investigate the influence of meal intake on iron absorption.
  • To compare iron absorption across different multivitamin formulations.

Main Methods:

  • Iron absorption was measured over eight hours in pregnant women (24-32 weeks gestation).
  • Absorption was assessed under fasting and postprandial conditions after a standardized meal.

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  • Five groups, including a control, used specific prenatal formulations (Natalins Rx, Prenatal 1/1, Stuartnatal Plus, Prenate 90) or a non-iron control.

    • Main Results:

    • Iron absorption varied significantly between formulations, with Prenate 90 showing the highest and Natalins Rx the lowest.
    • Postprandial iron absorption was generally higher than fasting absorption.
    • Three of the four supplements provided at least the recommended 3.0 mg of supplemental iron daily.

    Conclusions:

    • Differences in iron absorption are attributed to the complex interplay of vitamins, minerals, and additives.
    • The total elemental iron content does not guarantee its bioavailability.
    • Formulation composition is critical for ensuring adequate iron absorption during pregnancy.