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Nucleic acids and protein changes in normal and pre-eclamptic placentae

M B Sammour, F K Ibrahim, M M Fattah

    Acta Obstetricia Et Gynecologica Scandinavica
    |January 1, 1979
    PubMed
    Summary
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    In normal pregnancies, placental DNA, RNA, and proteins decrease after 28 weeks. Preeclampsia shows increased placental DNA and RNA, with proteins lower than in the second trimester.

    Area of Science:

    • Biochemistry
    • Obstetrics
    • Molecular Biology

    Background:

    • Placental development involves dynamic changes in nucleic acids and proteins.
    • Preeclampsia is a pregnancy complication associated with placental dysfunction.

    Purpose of the Study:

    • To investigate changes in placental DNA, RNA, and protein levels during normal pregnancy and preeclampsia.
    • To analyze the ratios of protein to DNA and RNA to DNA in these conditions.

    Main Methods:

    • Assay of DNA, RNA, and protein levels in placental tissue from three groups: normal second trimester, normal third trimester, and preeclampsia.
    • Calculation of protein/DNA and RNA/DNA ratios.

    Main Results:

    • In normal pregnancy, placental DNA, RNA, and protein levels decrease after 28 weeks.

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  • Preeclampsia exhibits significantly higher placental DNA and RNA compared to normal third-trimester pregnancy.
  • Protein levels in preeclampsia are elevated but remain below second-trimester concentrations, with altered protein/DNA and RNA/DNA ratios.

    • Conclusions:

    • Placental nucleic acid and protein profiles differ significantly between normal pregnancy and preeclampsia.
    • The observed changes in placental composition in preeclampsia may indicate altered cellular processes and contribute to the condition's pathophysiology.