Present concepts of coronary atherosclerosis-thrombosis, therapeutic implications and perspectives

Area of Science:

• Cardiovascular Medicine
• Pathophysiology
• Translational Research

Background:

• Coronary atherosclerosis knowledge has significantly evolved.
• Understanding of atherosclerotic lesion types, progression, and plaque instability has improved.
• Mechanisms of plaque disruption and subsequent thrombosis are better elucidated.

Purpose of the Study:

• To review the pathophysiology of coronary unstable atherosclerotic plaque.
• To discuss the thrombotic phenomena complicating unstable plaques.
• To highlight current and emerging therapeutic strategies.

Main Methods:

• Literature review focusing on recent advancements.
• Synthesis of current understanding of plaque biology and thrombosis.
• Analysis of therapeutic interventions for plaque stabilization and antithrombotic therapy.

Main Results:

• Improved comprehension of coronary plaque progression and instability.
• Enhanced understanding of the link between plaque rupture and acute coronary syndromes.
• Identification of novel therapeutic targets for lesion stabilization and thrombosis prevention.

Conclusions:

• Therapeutic strategies are shifting towards plaque stabilization and regression.
• New antithrombotic approaches are crucial for managing thrombotic complications.
• Further research is needed to translate these findings into clinical practice for acute coronary syndromes.