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Eczematous hypersensitivity from aqueous vitamin K injection
G C Keough1, J C English, J J Meffert
1Department of Dermatology, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA.
Cutis
|March 27, 1998
Summary
Injectable vitamin K treats hypoprothrombinemic states. A patient developed eczematous vitamin K1 hypersensitivity after treatment with aqueous vitamin K1 for warfarin-induced hypoprothrombinemia.
Area of Science:
- Dermatology
- Pharmacology
- Hematology
Background:
- Hypoprothrombinemic states necessitate vitamin K therapy.
- Cutaneous vitamin K hypersensitivity is historically linked to fat-soluble vitamin K1.
- Eczematous and sclerodermoid lesions characterize this hypersensitivity.
Observation:
- A patient with warfarin-induced hypoprothrombinemia received aqueous vitamin K1.
- The patient subsequently developed eczematous skin lesions.
Findings:
- The observed eczematous lesions were consistent with vitamin K1 hypersensitivity.
- This case suggests aqueous vitamin K1 can also elicit hypersensitivity reactions.
Implications:
- Clinicians should consider hypersensitivity to aqueous vitamin K1.
- Further investigation into vitamin K formulations and cutaneous reactions is warranted.
- This finding expands the understanding of adverse drug reactions to vitamin K.