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[Herpetic keratitis: clinical-virological correlation]

M J Martínez1, M Vogel, J Stoppel

  • 1Departamento de Microbiología, Facultad de Medicina, Universidad de Chile.

Revista Medica De Chile
|June 1, 1997
PubMed
Summary

Early diagnosis of herpetic keratitis is crucial. Polymerase chain reaction (PCR) is more sensitive than viral isolation for detecting herpes simplex virus (HSV) in stromal keratitis.

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Area of Science:

  • Ophthalmology
  • Virology
  • Infectious Diseases

Context:

  • Herpetic keratitis is a leading cause of corneal opacity.
  • Early diagnosis is essential for effective antiviral treatment.

Purpose:

  • To correlate clinical presentations of herpetic keratitis with virological diagnostic methods.
  • To evaluate the sensitivity of viral isolation and PCR in different forms of herpetic keratitis.

Summary:

  • A study of 41 patients with herpetic keratitis compared clinical features with viral detection methods.
  • Polymerase chain reaction (PCR) demonstrated higher sensitivity than viral isolation, particularly in stromal keratitis.
  • Herpes simplex virus type 2 (HSV-2) was rarely isolated, suggesting potential vertical transmission.

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Impact:

  • Highlights the diagnostic utility of PCR over viral isolation for stromal herpetic keratitis.
  • Suggests a possible autoimmune basis for stromal keratitis, especially in women.
  • Informs clinical practice regarding the choice of diagnostic tools for herpetic keratitis.