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A theoretical model for adhesion between cells mediated by multivalent ligands

G I Bell

    Cell Biophysics
    |June 1, 1979
    PubMed
    Summary
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    Cell-to-cell binding is modeled using bivalent ligands and mobile receptors. Receptor crosslinking before cell contact significantly hinders intercellular binding, impacting biological processes and experimental outcomes.

    Area of Science:

    • Biophysics
    • Cellular Biology
    • Theoretical Biology

    Background:

    • Cell-to-cell adhesion is crucial for multicellular organisms.
    • Ligand-receptor interactions mediate cell binding.
    • Receptor mobility on cell surfaces influences binding dynamics.

    Purpose of the Study:

    • To develop a theoretical model for cell-to-cell binding mediated by bivalent ligands.
    • To investigate the role of mobile receptors and monovalent inhibitors in binding.
    • To analyze the impact of receptor crosslinking on intercellular bridge formation.

    Main Methods:

    • Development of a theoretical model incorporating bivalent ligands and mobile receptors.
    • Inclusion of monovalent inhibitors targeting receptors or ligands.

    Related Experiment Videos

  • Analysis of equilibrium and kinetic aspects of cell binding.

    • Main Results:

    • Symmetrical bivalent ligands can lead to receptor crosslinking on cell surfaces.
    • Receptor crosslinking interferes with intercellular bridge formation.
    • Pre-formation of crosslinks before cell contact significantly impedes binding rates.

    Conclusions:

    • Receptor mobility is a critical factor in cell-to-cell binding dynamics.
    • Ligand-mediated crosslinking can act as a regulatory mechanism for cell adhesion.
    • The model provides insights into experimental observations and potential therapeutic strategies.