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Factor V Leiden mutation in patients with Behçet's disease
1Department of Pediatric Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
The Journal of Rheumatology
|March 28, 1998
Summary
Factor V Leiden mutation, a risk factor for thrombosis, was found in 22.7% of Behçet's disease patients. While not always causing venous thrombosis, it may contribute to thromboembolic events in Behçet's disease.
Area of Science:
- Vascular Medicine
- Genetics
- Rheumatology
Background:
- Behçet's disease (BD) is a chronic vasculitis potentially linked to anticoagulant pathways.
- Factor V Leiden is a genetic mutation affecting blood coagulation.
Purpose of the Study:
- To investigate the association between factor V Leiden mutation and Behçet's disease.
- To assess if factor V Leiden is a risk factor for thrombosis in BD patients.
Main Methods:
- Polymerase chain reaction was used to detect factor V Leiden in 44 BD patients.
- Patients' thrombotic history was recorded and analyzed in relation to mutation status.
Main Results:
- The factor V Leiden mutation frequency in BD patients was 22.7%, significantly higher than the general population (7.1%).
- Among BD patients with a history of thrombosis, 60% carried the mutation.
- Thrombosis occurred in 30% of BD patients with factor V Leiden versus 5.9% without.
Conclusions:
- Factor V Leiden (homozygosity or heterozygosity) may be a contributing risk factor for venous thromboembolic events in Behçet's disease.
- The presence of factor V Leiden does not guarantee thrombosis in BD patients but increases the risk.