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Updated: Aug 1, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
[Clinical-immunological research in chronic inflammatory diseases of the biliary tract]
A V Iepishyn1, P Ia Sherstiuk, N A Khabarova
1Kafedra propedevtyky vnutrishnikh khvorob, kafedra terapiï FPO Ternopol'skoï medychnoï akademiï im. I.Ia. Horbachevs'koho.
Abstract:
Complex investigation of the immune state of 123 patients with chronic inflammatory diseases of biliary system (CDBS) was conducted. The reduce of T-lymphocytes quantity and functional activity, their subpopulations, level of complement, the blood serum lysozyme, the increase of B-lymphocytes content, serumal IgG, IgM, circulating immune complexes (CIC), the antibodies titer to the gallbladder tissue, liver, pancreas, and level of the lymphocytes sensibilization to these antigens in the acute period of the disease. Presence of calculi in gallbladder, coexistence of cholecystitis with reactive hepatitis or pancreatitis caused more significant changes in immune system.
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